This RCT aims to investigate the effects of an individually tailored, multidisciplinary outpatient rehab programme (consisting of aerobic training, cognitive behaviour therapy and energy management strategies), as compared to consultation by an MS nurse, focusing on energy conservation and stimulating physical activity.

Surprisingly, and contrary to hypothesis, fatigue showed to be quite invariant from baseline onwards, as measured by several checklists for fatigue, QoL and functional activities. No treatment effects could be demonstrated.