This clinical practice guideline on the management of total knee arthroplasty (TKA) by the American Physical Therapy Association (APTA) is the result of a systematic review, which found 192 studies eligible for review.

Several factors were taken into account when determining the strength of recommendations. Among others: study quality; magnitude of benefit vs. risk, harms, and costs; quality, quantity, and trade-off between treatment benefits and harms; magnitude of treatment effect; and data on critical outcomes.

The strength of recommendations ranged from best practice/ theoretical/ foundational to strong, with well-defined criteria for each.