Lateral ankle sprains are the most prevalent musculoskeletal injury of the lower limb in physical active individuals. A large proportion of individuals with a previous experienced ankle injury history will experience persistent pain, swelling, and develop what is commonly referred as chronic ankle instability (CAI). Individuals with a CAI experience greater self-reported functional limitations. Although the international ankle consortium advocated the evaluation of effectiveness of therapies, the results are inconsistent. Thus, a systematic review was needed that identified the most effective therapeutic interventions for improving self-reported function.