Nearly 2 million mild traumatic brain injuries (mTBI) occur each year in the United States alone, with concussion being a world-wide issue for healthcare management.

One of the main symptoms associated with mTBI is cognitive fatigue - defined as “a subjective lack of physical and/ or mental energy that is perceived by the individual or caregiver to interfere with usual and desired activities.”

This article focuses the sources of primary fatigue, directly related to the mTBI, whereas secondary cognitive fatigue is related to poor sleep and resulting in day-time fatigue.