There has been relatively little work done to develop interventions for fatigue following TBI in general, and the evidence is highly variable for recommendations around mTBI fatigue.
The main advice is around sleep hygiene and regulating a schedule that adheres to pacing, and avoids a ‘boom and bust’ pattern of doing too much.
An other, lesser known management modality of mTBI associated fatigue is medication. Methylphenidate (a dopamine agonist) may help overcome attentional difficulties and reported cognitive difficulties. Melatonin is also sometimes used to help promote greater quality of sleep, with hopes of improving cognitive fatigue - but this is addressing the secondary rather than the primary source of cognitive fatigue following mTBI.
Cognitive behavioural therapy (CBT) has also been found beneficial when managing cognitive fatigue. It is felt that, in conjunction with other functional interventions (such as light exercise), structuring of schedules and days as well as cognitive retraining, anxiety-reducing techniques and education around proper energy management techniques can help improve cognitive fatigue.
Even the application of mindfulness alongside of CBT can be helpful as mindfulness can work in 2 ways: increasing self-awareness as well as decreasing cognitive stimuli output and processing for a brief period.