Peripheral and central sensitization in shoulder pain
The influence of central and peripheral sensitization processes on perception of pain, recovery and the development of chronic pain are recently receiving attention in clinical research. This study employed several experimental pain sensitivity testing procedures to investigate if response to pain in the affected and non-affected side of patients with shoulder pain differed from those in asymptomatic controls.
58 patients with shoulder pain and 56 pain free age-matched and sex-matched controls were included in this study. All subjects completed standard questionnaires regarding demographic and psychological characteristics (Fear of Pain Questionnaire, Pain Catastrophizing Scale and Tampa Scale of Kinesiophobia) prior to testing. Testing procedures included pressure and thermal pain sensitivity testing.
Both evidence for peripheral sensitization (i.e. side-to-side difference in pressure sensitivity) as well as evidence for central sensitization (i.e. bilateral pressure and thermal hypersensitivity in local and remote regions as compared to asymptomatic subjects) in patients with unilateral shoulder pain. Interestingly, no consistent sensitization patterns were present in this population, indicating heterogeneity in pain processing for musculoskeletal disorders.
> From: Coronado et al., Clin J Pain 30 (2015) 143-151. All rights reserved to Lippincott, Williams & Wilkins. Click here for the Pubmed summary.