Carpal tunnel syndrome (CTS) is due to compression of the median nerve and is the most commonly occurring compression neuropathy. Due to the varied etiopathogenesis of CTS, it remains a challenge for clinicians, as inadequate studies exist regarding conservative treatment. Based on the promising results of previous studies with manual therapy, the authors of the current study wanted to investigate the use of fascial manipulation (FM) versus low level laser therapy (LLLT) in the management of CTS. In general, it was shown that, while both LLLT and FM improve outcomes, FM had better long term effects than LLT.