Repetitive use injuries of the upper extremity form a large proportion of work related injuries. To date the literature has been mixed on the efficacy of various modalities to treat and reverse the deleterious effects of these sorts of injuries. Due to symptoms of pain and motor dysfunction patients often neglect and fail to use there effected limb resulting in the development of tissue fibrosis. Tissue samples are shown to be associated with increased fibrogenic tissue markers. With this in mind, the authors of the present study investigated the roles manual therapy can have on repetitive use injuries on both behavior and at the cellular level. Overall it was shown that when compared to control, rats receiving modeled manual therapy (MMT) expressed fewer discomfort related behaviors and had less fibrotic tissue changes.